Dr. John A. Wolf is an Associate Professor of Neurosurgery at the University of Pennsylvania and a Research Scientist at the Corporal Michael J. Crescenz VA Medical Center. Trained as a computational and systems neuroscientist, Dr. Wolf investigates how traumatic brain injury disrupts limbic circuit dynamics — particularly within the hippocampus, prefrontal cortex, and amygdala — and how those disruptions drive cognitive impairment, post-traumatic epilepsy, and PTSD-related sequelae. His laboratory employs chronically implanted high-density electrophysiology in a translational porcine model to characterize aberrant synchrony, hyperexcitability, and epileptiform activity in vivo. A central focus is understanding how injured circuits compensate — and what ultimately overwhelms that compensation. This systems perspective drives his neuromodulation research, which aims to identify therapeutic targets and restore healthy circuit dynamics following TBI.